Mitochondrial Glutathione in Cellular Redox Homeostasis and Disease Manifestation Not only that, it depletes your #glutathione levels! Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite Journal of Neuroscience Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic