Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert!