Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation Sex differences in glutathione metabolism and acetaminophen toxicity