Activation of IGF 1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy Scientific Reports Mechanisms of IGF 1 Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy Crucial role of androgen receptor in resistance and endurance trainings induced muscle hypertrophy through IGF 1 IGF 1R PI3K Akt mTOR pathway Nutrition & Metabolism Springer Nature Link IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice in: Journal of Endocrinology Volume 234 Issue 2 (2017)