Glutathione and Vitamin C: Better Together? Performance Lab Glutathione detoxifies your liver, protects your mitochondria, drives down inflammation, and handles about half of your body's antioxidant defense on its own. To push those benefits further, most people assume they need Vitamin C vs Glutathione whats the difference? Both brighten the look of skin but they work in different ways. Vitamin C helps visibly brighten and improve the appearance of sun damage while Glutathione vs Vitamin C: Which Is Better for Skin Glowing?